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Sci Rep. 2017 Aug 17;7(1):8639. doi: 10.1038/s41598-017-09379-8.

Long Term Glaucoma Drug Delivery Using a Topically Retained Gel/Microsphere Eye Drop.

Fedorchak MV1,2,3,4,5,6, Conner IP7,8,9, Schuman JS7,8,10,11,9,12,13,14,15, Cugini A11, Little SR16,17,18,19,20.

Author information

1
UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA. fedorchak@pitt.edu.
2
The Louis J. Fox Center for Vision Restoration, University of Pittsburgh, Pittsburgh, PA, USA. fedorchak@pitt.edu.
3
Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA. fedorchak@pitt.edu.
4
Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, USA. fedorchak@pitt.edu.
5
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. fedorchak@pitt.edu.
6
The McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. fedorchak@pitt.edu.
7
UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA.
8
The Louis J. Fox Center for Vision Restoration, University of Pittsburgh, Pittsburgh, PA, USA.
9
The McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
10
Department of Clinical and Translational Science, University of Pittsburgh, Pittsburgh, PA, USA.
11
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
12
Department of Ophthalmology, Langone Eye Center, NYU School of Medicine, New York, NY, USA.
13
Department of Neuroscience, NYU School of Medicine, New York, NY, USA.
14
Department of Physiology, NYU School of Medicine, New York, NY, USA.
15
Depatment of Electrical and Computer Engineering, NYU Tandon School of Engineering, New York, NY, USA.
16
UPMC Eye Center, Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, USA. srlittle@pitt.edu.
17
Department of Chemical Engineering, University of Pittsburgh, Pittsburgh, PA, USA. srlittle@pitt.edu.
18
Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. srlittle@pitt.edu.
19
Department of Immunology, University of Pittsburgh, Pittsburgh, PA, USA. srlittle@pitt.edu.
20
The McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. srlittle@pitt.edu.

Abstract

The purpose of this study was to characterize and determine the efficacy of a long-term, non-invasive gel/microsphere (GMS) eye drop for glaucoma. This novel drug delivery system is comprised of a thermoresponsive hydrogel carrier and drug-loaded polymer microspheres. In vitro release of brimonidine from the GMS drops and gel properties were quantified. A single brimonidine-loaded GMS drop was administered to 5 normotensive rabbits and intraocular pressure (IOP) was monitored for 28 days. Here we report that IOP reduction in rabbits receiving a single brimonidine GMS drop was comparable to that of rabbits receiving twice daily, standard brimonidine drops. GMS drops were retained in the inferior fornix in all animals for the length of the study. Our results suggest in vivo efficacy over 28 days from a single GMS drop and a potential decrease in systemic absorption, based on a lack of substantial IOP effects on the fellow untreated eye, compared to brimonidine twice-daily eye drops. To our knowledge, this represents the first long-term, drug-releasing depot that can be administered as a traditional eye drop.

PMID:
28819134
PMCID:
PMC5561248
DOI:
10.1038/s41598-017-09379-8
[Indexed for MEDLINE]
Free PMC Article

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