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Nat Commun. 2017 Aug 17;8(1):293. doi: 10.1038/s41467-017-00311-2.

The non-coding RNA BC1 regulates experience-dependent structural plasticity and learning.

Author information

1
KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, Leuven, 3000, Belgium.
2
VIB Center for Brain & Disease Research, Department of Neurosciences KU Leuven, Leuven, 3000, Belgium.
3
Institute of Cell Biology and Neurobiology, CNR, Roma, 00015, Italy.
4
Program in Neurosciences and Mental Health, Hospital for Sick Children, Toronto, ON, M5G 1X8, Canada.
5
Department of Fundamental Neurosciences, University of Lausanne, Lausanne, 1005, Switzerland.
6
Department of Microbiology and Immunology, KU Leuven, Leuven, 3000, Belgium.
7
Department of Neuroscience, Karolinska Institutet, Stockholm, 171 77, Sweden.
8
National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, MD, 20852, USA.
9
VIB Electron Microscopy Platform & Bio Imaging Core, VIB-KU Leuven Center for Brain & Disease Research, Department of Neurosciences KU Leuven, Leuven, 3000, Belgium.
10
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, 00173, Italy.
11
Department of Biology, Laboratory of Neuroplasticity and Neuroproteomics, KU Leuven, Leuven, 3000, Belgium.
12
Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive Research, VU University, Amsterdam, 1081, The Netherlands.
13
Department of Systems Neuroscience, Medical Faculty Bochum, Ruhr-University, Bochum, 44801, Germany.
14
KU Leuven, Department of Neurosciences, Leuven Research Institute for Neuroscience and Disease (LIND), KU Leuven, Leuven, 3000, Belgium. claudia.bagni@unil.ch.
15
VIB Center for Brain & Disease Research, Department of Neurosciences KU Leuven, Leuven, 3000, Belgium. claudia.bagni@unil.ch.
16
Department of Fundamental Neurosciences, University of Lausanne, Lausanne, 1005, Switzerland. claudia.bagni@unil.ch.
17
Department of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, 00173, Italy. claudia.bagni@unil.ch.

Abstract

The brain cytoplasmic (BC1) RNA is a non-coding RNA (ncRNA) involved in neuronal translational control. Absence of BC1 is associated with altered glutamatergic transmission and maladaptive behavior. Here, we show that pyramidal neurons in the barrel cortex of BC1 knock out (KO) mice display larger excitatory postsynaptic currents and increased spontaneous activity in vivo. Furthermore, BC1 KO mice have enlarged spine heads and postsynaptic densities and increased synaptic levels of glutamate receptors and PSD-95. Of note, BC1 KO mice show aberrant structural plasticity in response to whisker deprivation, impaired texture novel object recognition and altered social behavior. Thus, our study highlights a role for BC1 RNA in experience-dependent plasticity and learning in the mammalian adult neocortex, and provides insight into the function of brain ncRNAs regulating synaptic transmission, plasticity and behavior, with potential relevance in the context of intellectual disabilities and psychiatric disorders.Brain cytoplasmic (BC1) RNA is a non-coding RNA that has been implicated in translational regulation, seizure, and anxiety. Here, the authors show that in the cortex, BC1 RNA is required for sensory deprivation-induced structural plasticity of dendritic spines, as well as for correct sensory learning and social behaviors.

PMID:
28819097
PMCID:
PMC5561022
DOI:
10.1038/s41467-017-00311-2
[Indexed for MEDLINE]
Free PMC Article

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