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J Clin Psychiatry. 2017 Sep/Oct;78(8):e1000-e1005. doi: 10.4088/JCP.16m11404.

Preventive Effects of Lamotrigine in Bipolar II Versus Bipolar I Disorder.

Author information

1
Department of Neuropsychiatry, Oita University Faculty of Medicine, Oita, Japan.
2
Post-Marketing Surveillance Department, Development & Medical Affairs Division, GlaxoSmithKline K.K., 6-15, Sendagaya 4-chome, Shibuya-ku, Tokyo 151-8566, Japan. atsuko.2.ishida@gsk.com.
3
Post-Marketing Surveillance Department, GlaxoSmithKline K.K., Tokyo, Japan.
4
MA Specialty & General Care Medicine Department, GlaxoSmithKline K.K., Tokyo, Japan.
5
Biomedical Data Sciences Department, GlaxoSmithKline K.K., Tokyo, Japan.

Abstract

OBJECTIVE:

The preventive effects of mood stabilizers on recurrence/relapse in bipolar disorders have been investigated mostly in bipolar I disorder (BPI) patients, with limited reports on bipolar II disorder (BPII) patients. Here, we conducted an explorative data analysis to investigate whether the preventive effect of lamotrigine on recurrence /relapse in BPII is better than in BPI.

METHODS:

Data from Japanese patients with a diagnosis of BPI or BPII according to DSM-IV-TR were analyzed in an open-label, noninterventional, naturalistic, prospective postmarketing surveillance study of lamotrigine. This study was carried out from October 2011 to November 2014, and each patient was observed for 1 year. The time to recurrence/relapse of mood episodes after commencement of lamotrigine treatment was evaluated as a primary endpoint. Kaplan-Meier curves were generated to compare the time to recurrence/relapse of mood episodes in BPI with in BPII using a log-rank test.

RESULTS:

Lamotrigine was associated with a significantly longer time to recurrence/relapse of mood episodes in BPII than in BPI (log-rank test, P = .0103). Lamotrigine also prolonged time to recurrence/relapse of mania-related episodes, including hypomanic episodes, more in BPII than in BPI (P = .0110).

CONCLUSIONS:

Although the preventive effect of lamotrigine on recurrence/relapse of mood episodes in BPI has been established in a variety of clinical studies, the present study suggests that lamotrigine may be more suitable for maintenance treatment in BPII than in BPI.

PMID:
28817765
DOI:
10.4088/JCP.16m11404
[Indexed for MEDLINE]
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