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Diabetes Metab Res Rev. 2017 Oct;33(7). doi: 10.1002/dmrr.2929. Epub 2017 Sep 11.

Dysregulation of wound healing mechanisms in diabetes and the importance of negative pressure wound therapy (NPWT).

Author information

1
Internal Medicine D and Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
2
Institute of Endocrinology, Diabetes and Metabolism, Rambam Health Care Campus, Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Abstract

Diabetes is a serious disease with severe side effects and comorbidities. Diabetic foot with its chronic nonhealing ulcers, or diabetic foot ulcers, as they are commonly called, can be devastating, even leading to amputation. Many therapies exist to assist and improve wound healing. One exciting discovery is the use of negative pressure wound therapy (NPWT) as an adjunct to standard treatment. Few studies have substantively explored the molecular mechanisms of NPWT and why we see improved wound healing, a concept that demands more research. The following commentary summarizes the current literature regarding NPWT as well as some of the vast body of work that focuses on the physiologic mechanisms of wound healing in diabetics in general.

KEYWORDS:

diabetic foot ulcer; negative pressure wound therapy; poor wound healing

PMID:
28817237
DOI:
10.1002/dmrr.2929
[Indexed for MEDLINE]

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