Format

Send to

Choose Destination
Gut Microbes. 2018 Jan 2;9(1):68-75. doi: 10.1080/19490976.2017.1356979. Epub 2017 Aug 28.

Application of the distance-based F test in an mGWAS investigating β diversity of intestinal microbiota identifies variants in SLC9A8 (NHE8) and 3 other loci.

Author information

1
a Institute of Clinical Molecular Biology , Christian-Albrechts-University of Kiel , Kiel , Germany.
2
b Evolutionary Genomics , Max Planck Institute for Evolutionary Biology , Plön , Germany.
3
c Institute for Experimental Medicine , Christian-Albrechts-University of Kiel , Kiel , Germany.
4
d Norwegian PSC Research Center, Division of Surgery, Inflammatory Medicine and Transplantation , University Hospital Rikshospitalet , Oslo , Norway.
5
e K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine , University of Oslo , Oslo , Norway.
6
f Research Institute of Internal Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.
7
g Section of Gastroenterology, Department of Transplantation Medicine , Oslo University Hospital Rikshospitalet , Oslo , Norway.
8
h Institute of Epidemiology , Christian-Albrechts-University of Kiel , Kiel , Germany.
9
i Department of Clinical Medicine , University of Bergen , Bergen , Norway.
10
j Department of Internal Medicine I , University Hospital S.-H. (UKSH, Campus Kiel) , Kiel , Germany.

Abstract

Factors shaping the human intestinal microbiota range from environmental influences, like smoking and exercise, over dietary patterns and disease to the host's genetic variation. Recently, we could show in a microbiome genome-wide association study (mGWAS) targeting genetic variation influencing the β diversity of gut microbial communities, that approximately 10% of the overall gut microbiome variation can be explained by host genetics. Here, we report on the application of a new method for genotype-β-diversity association testing, the distance-based F (DBF) test. With this we identified 4 loci with genome-wide significant associations, harboring the genes CBEP4, SLC9A8, TNFSF4, and SP140, respectively. Our findings highlight the utility of the high-performance DBF test in β diversity GWAS and emphasize the important role of host genetics and immunity in shaping the human intestinal microbiota.

KEYWORDS:

GWAS; IBD; human gut microbiota; immunity; β diversity

PMID:
28816579
PMCID:
PMC5939986
DOI:
10.1080/19490976.2017.1356979
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central Icon for Norwegian BIBSYS system
Loading ...
Support Center