Format

Send to

Choose Destination
J Cell Physiol. 2018 Apr;233(4):2693-2694. doi: 10.1002/jcp.26155. Epub 2017 Sep 18.

The silent enemy: Celiac disease goes viral.

Author information

1
Department of Molecular Medicine, University of Padua, Padua, Italy.

Abstract

Celiac disease is a multifactorial autoimmune chronic inflammatory disorder affecting approximately one percent of the worldwide population. In such patients, ingestion of gluten proteins from cereals like wheat, barley, and rye causes damage of the small intestine mucosa, with potentially severe consequences. Onset of the disease in predisposed individuals is believed to require a still not clearly identified external trigger, such as viral infections. A very recent study has begun to shed light on a possible mechanistic basis for this hypothesis, and surprisingly linked intestinal infections caused by common reoviruses to the onset of celiac disease.

KEYWORDS:

autoimmunity; celiac disease pathogenesis; dietary antigens tolerance; gluten tolerance; reovirus

PMID:
28816347
DOI:
10.1002/jcp.26155

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center