Format

Send to

Choose Destination
Sci Rep. 2017 Aug 16;7(1):8431. doi: 10.1038/s41598-017-08762-9.

Dual Contrast - Magnetic Resonance Fingerprinting (DC-MRF): A Platform for Simultaneous Quantification of Multiple MRI Contrast Agents.

Author information

1
Department of Radiology, Case Western Reserve University, Cleveland, OH, USA.
2
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA.
3
Frances Payne Bolton School of Nursing, Case Western Reserve University, Cleveland, OH, USA.
4
Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, USA.
5
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA.
6
Department of Molecular Biology and Microbiology, Case Western Reserve University, Cleveland, OH, USA.
7
Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
8
Department of Materials Science and Engineering, Case Western Reserve University, Cleveland, OH, USA.
9
Department of Macromolecular Science and Engineering, Case Western Reserve University, Cleveland, OH, USA.
10
Division of General Medicine-Oncology, Case Western Reserve University, Cleveland, OH, USA.
11
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH, USA.
12
Department of Radiology, Case Western Reserve University, Cleveland, OH, USA. caf@case.edu.
13
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, USA. caf@case.edu.
14
Department of Pediatrics, Case Western Reserve University, Cleveland, OH, USA. caf@case.edu.

Abstract

Injectable Magnetic Resonance Imaging (MRI) contrast agents have been widely used to provide critical assessments of disease for both clinical and basic science imaging research studies. The scope of available MRI contrast agents has expanded over the years with the emergence of molecular imaging contrast agents specifically targeted to biological markers. Unfortunately, synergistic application of more than a single molecular contrast agent has been limited by MRI's ability to only dynamically measure a single agent at a time. In this study, a new Dual Contrast - Magnetic Resonance Fingerprinting (DC - MRF) methodology is described that can detect and independently quantify the local concentration of multiple MRI contrast agents following simultaneous administration. This "multi-color" MRI methodology provides the opportunity to monitor multiple molecular species simultaneously and provides a practical, quantitative imaging framework for the eventual clinical translation of molecular imaging contrast agents.

Supplemental Content

Full text links

Icon for Nature Publishing Group Icon for PubMed Central
Loading ...
Support Center