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Nat Prod Res. 2018 Sep;32(17):2111-2115. doi: 10.1080/14786419.2017.1365067. Epub 2017 Aug 17.

Neuraminidase inhibitory activity by compounds isolated from aerial parts of Rhinacanthus nasutus.

Author information

1
a College of Pharmacy , Yonsei Institute of Pharmaceutical Sciences, Yonsei University , Incheon , Korea.
2
b Institute of Marine Biochemistry , Vietnam Academy of Science and Technology , Hanoi , Vietnam.

Abstract

Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of various diseases, such as cancer, fungal infections, herpes virus infections and several types of skin diseases in South-East Asian countries. In this study, eight compounds 1-8 were isolated from the aerial parts of R. nasutus. The structures of compounds were determined by the spectroscopic methods, including 1D and 2D NMR. The isolated compounds were evaluated for neuraminidase inhibitory activity. Several lignans, 2,3-bis[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-1,4-butanediol (5) and 8,8'-bisdihydrosiringenin glucoside (6), significantly inhibited neuraminidase activity, which was comparable to the positive controls, mangiferin and oseltamivir. In addition, a structure-based virtual screening against neuraminidase using bioactive components was demonstrated.

KEYWORDS:

Rhinacanthus nasutus; lignan; neuraminidase

PMID:
28814115
DOI:
10.1080/14786419.2017.1365067
[Indexed for MEDLINE]

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