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Immunity. 2017 Aug 15;47(2):224-233. doi: 10.1016/j.immuni.2017.07.009.

Fcγ Receptor Function and the Design of Vaccination Strategies.

Author information

1
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA.
2
Laboratory of Molecular Genetics and Immunology, The Rockefeller University, 1230 York Avenue, New York, NY 10065, USA. Electronic address: ravetch@rockefeller.edu.

Abstract

Through specific interactions with distinct types of Fcγ receptors (FcγRs), the Fc domain of immunoglobulin G (IgG) mediates a wide spectrum of immunological functions that influence both innate and adaptive responses. Recent studies indicate that IgG Fc-FcγR interactions are dynamically regulated during an immune response through the control of the Fc-associated glycan structure and Ig subclass composition on the one hand and selective FcγR expression on immune cells on the other, which together determine the capacity of IgG to interact in a cell-type-specific manner with specific members of the FcγR family. Here, we present a framework that synthesizes the current understanding of the contribution of FcγR pathways to the induction and regulation of antibody and T cell responses. Within this context, we discuss vaccination strategies to elicit broad and potent immune responses based on the immunomodulatory properties of Fc-FcγR interactions.

KEYWORDS:

antibodies; effector functions; immune regulation; immunity; immunization; therapy; vaccination

PMID:
28813656
PMCID:
PMC5573140
DOI:
10.1016/j.immuni.2017.07.009
[Indexed for MEDLINE]
Free PMC Article

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