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Immunity. 2017 Aug 15;47(2):203-208. doi: 10.1016/j.immuni.2017.07.010.

A Case for a Human Immuno-Peptidome Project Consortium.

Author information

1
Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland. Electronic address: caron@imsb.biol.ethz.ch.
2
Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland; Faculty of Science, University of Zürich, Zürich, Switzerland.
3
Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland; PhD Program in Systems Biology, Life Science Zurich Graduate School, University of Zurich and ETH Zurich, Zurich, Switzerland.
4
Department of Oncology, University Hospital of Lausanne; Ludwig Center for Cancer Research of the University of Lausanne, Lausanne, Switzerland.
5
Department of Oncology, University Hospital of Lausanne; Ludwig Center for Cancer Research of the University of Lausanne, Lausanne, Switzerland. Electronic address: michal.bassani@chuv.ch.

Abstract

A multidisciplinary group of researchers gathered at the Hönggerberg Campus at ETH Zurich, Switzerland, for the first meeting on the Human Immuno-Peptidome Project (https://hupo.org/human-immuno-peptidome-project/). The long-term goal of this project is to map the entire repertoire of peptides presented by human leukocyte antigen molecules using mass spectrometry technologies, and make its robust analysis accessible to any immunologist. Here we outline the specific challenges identified toward this goal, and within this framework, describe the structure of a multipronged program aimed at addressing these challenges and implementing solutions at a community-wide level. Pillars of that program are: (1) method and technology development, (2) standardization, (3) effective data sharing, and (4) education. If successful, this community-driven endeavor might provide a roadmap toward new paradigms in immunology.

PMID:
28813649
DOI:
10.1016/j.immuni.2017.07.010
[Indexed for MEDLINE]
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