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Annu Rev Med. 2018 Jan 29;69:165-176. doi: 10.1146/annurev-med-041316-090545. Epub 2017 Aug 16.

Understanding Peripartum Cardiomyopathy.

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Cardiovascular Institute, University of Pennsylvania, Philadelphia, Pennsylvania 19104; email:


Peripartum cardiomyopathy (PPCM) is the unexplained loss of maternal cardiac systolic function in the period surrounding parturition. PPCM affects women worldwide and is a leading cause of maternal mortality. The cause of PPCM has remained elusive until recently. We review here the epidemiology of PPCM, recent findings that strongly indicate hormonal and genetic contributions to the development of PPCM, and implications for the management of women with PPCM.


African-American; peripartum cardiomyopathy; preeclampsia; prolactin; sFlt1

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