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Virulence. 2017 Nov 17;8(8):1580-1591. doi: 10.1080/21505594.2017.1365216. Epub 2017 Aug 25.

Novel Influenza D virus: Epidemiology, pathology, evolution and biological characteristics.

Author information

1
a Jiangsu Engineering Laboratory of Animal Immunology , Institute of Immunology and College of Veterinary Medicine, Nanjing Agricultural University , Nanjing , China.
2
b Key Laboratory of Zoonosis Prevention and Control of Guangdong Province and College of Veterinary Medicine , South China Agricultural University , Guangzhou , China.
3
c Institute for Virology, Center for Infection Medicine, Veterinary Faculty , Free University Berlin , Berlin , Germany.

Abstract

In 2011, a new virus was isolated from pigs with influenza-like symptoms and subsequently also from cattle, which are the main reservoir of the virus. It is similar to Influenza C virus (ICV), a (predominantly) human pathogen, causing respiratory disease in children. Since the virus is unable to reassort with ICV (and based on several other criteria as discussed in the text) it is now officially named as Influenzavirus D (IDV), a new genus of the Orthomyxoviridae. We summarize the epidemiology, pathology and evolution of IDV and its biological characteristics with emphasis on the only glycoprotein HEF. Based on the limited data available we finally consider whether IDV represent a public health threat.

KEYWORDS:

HEF; Influenzavirus D; bovine; cattle; epidemiology; evolution; pathology; zoonosis

PMID:
28812422
PMCID:
PMC5810478
DOI:
10.1080/21505594.2017.1365216
[Indexed for MEDLINE]
Free PMC Article

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