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Magn Reson Med. 2018 Apr;79(4):2254-2264. doi: 10.1002/mrm.26872. Epub 2017 Aug 15.

Murine pulmonary imaging at 7T: T2* and T1 with anisotropic UTE.

Author information

1
Center for Pulmonary Imaging Research, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
2
Department of Physics, Washington University in St. Louis, St. Louis, Missouri, USA.
3
Department of Physics, University of Cincinnati, Cincinnati, Ohio, USA.

Abstract

PURPOSE:

To measure the T2* and T1 of mouse lung at 7T via anisotropic-resolution radial ultrashort echo-time imaging with ellipsoidal k-space coverage.

METHODS:

Ellipsoidal field-of-view was created by expanding uniform spherical k-space coverage. The effects of T2* and ellipsoidal sampling on image resolution were investigated by using point-spread-function analysis and resolution phantoms. Finally, this ellipsoidal sampling approach was used to measure the lung T2* and T1 of healthy C57BL/6 mice at the increasingly common preclinical field strength of 7T.

RESULTS:

Lung parenchyma T2* of 17- to 23-week-old mice at 7T was 0.395 ± 0.033 ms. T1 of lung and left- and right-heart ventricles was 1452.5 ± 87.0 ms, 1810.5 ± 54.6 ms, and 1602.6 ± 120.9 ms, respectively. Ellipsoidal k-space sampling provides enhanced resolution for a fixed scanning time or provides equivalent (although anisotropic) spatial resolution with reduced scanning times, while simultaneously avoiding fold-in artifacts.

CONCLUSION:

Using these techniques, the first T2* and T1 measures of mouse lung at 7T are reported. Ultrashort echo-time imaging with ellipsoidal k-space coverage significantly increases in-plane resolution without increasing scanning time, or equivalently, decreases scanning time while maintaining equivalent in-plane resolution. Magn Reson Med 79:2254-2264, 2018. © 2017 International Society for Magnetic Resonance in Medicine.

KEYWORDS:

T2*; T1; ellipsoidal k-space coverage; murine lung; UTE MRI

PMID:
28812309
PMCID:
PMC5811363
[Available on 2019-04-01]
DOI:
10.1002/mrm.26872

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