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Cardiol Res Pract. 2017;2017:4751249. doi: 10.1155/2017/4751249. Epub 2017 Jul 24.

Divorce and Severity of Coronary Artery Disease: A Multicenter Study.

Author information

1
Section of Adult Cardiology, Cardiovascular Department, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia.
2
Cardiovascular Department, Armed Forces Hospital Southern Region, Khamis Mushayt, Saudi Arabia.
3
Cardiology Department, Zayed Military Hospital, Abu Dhabi, UAE.
4
Division of Cardiology, Baystate Medical Center, Tufts University School of Medicine, Springfield, MA, USA.
5
Cardiac Center, King Abdullah Medical City, Holy Capital, Makkah, Saudi Arabia.
6
Section of Pulmonology, Internal Medicine Department, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia.
7
Division of Gastroenterology and Hepatology, The Johns Hopkins Hospital, 1830 East Monument Street, Suite 428, Baltimore, MD 21287, USA.
8
Anesthesiology Department, King Faisal Specialist Hospital & Research Center, Riyadh, Saudi Arabia.
9
Emergency Medicine Department, Cleveland Clinic Foundation, Cleveland, OH, USA.
10
Cardiology Unit, King Abdul Aziz University Hospital, Jeddah, Saudi Arabia.
11
Anesthesiology Department, King Abdul Aziz University Hospital, Jeddah, Saudi Arabia.
12
Suez Canal University, Ismailia, Egypt.
13
College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, UAE.
14
Institute of Cardiac Sciences, Sheikh Khalifa Medical City, Abu Dhabi, UAE.

Abstract

The association between marital status and coronary artery disease (CAD) is supported by numerous epidemiological studies. While divorce may have an adverse effect on cardiac outcomes, the relationship between divorce and severe CAD is unclear. We conducted a multicenter, observational study of consecutive patients undergoing coronary angiography during the period between April 1, 2013, and March 30, 2014. Of 1,068 patients, 124 (12%) were divorced. Divorce was more frequent among women (27%) compared to men (6%). Most divorced patients had been divorced only once (49%), but a subset had been divorced 2 (38%) or ≥3 (12%) times. After adjusting for baseline differences, there was no significant association between divorce and severe CAD in men. In women, there was a significant adjusted association between divorce and severe MVD (OR 2.31 [1.16, 4.59]) or LMD (OR 5.91 [2.19, 15.99]). The modification of the association between divorce and severe CAD by gender was statistically significant for severe LMD (Pinteraction 0.0008) and marginally significant for CAD (Pinteraction 0.05). Among women, there was a significant adjusted association between number of divorces and severe CAD (OR 2.4 [95% CI 1.2, 4.5]), MVD (OR 2.0 [95% CI 1.4, 3.0]), and LMD (OR 3.4 [95% CI 1.9, 5.9]). In conclusion, divorce, particularly multiple divorces, is associated with severe CAD, MVD, and LMD in women but not in men.

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