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Development. 2017 Aug 15;144(16):2862-2872. doi: 10.1242/dev.153163.

Wilms' tumour 1 (WT1) in development, homeostasis and disease.

Author information

1
MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Crewe Road (S), Edinburgh, EH4 2XU, UK nick.hastie@igmm.ed.ac.uk.

Abstract

The study of genes mutated in human disease often leads to new insights into biology as well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple roles in development, tissue homeostasis and disease. In this Primer, I summarise how this multifaceted gene functions in various mammalian tissues and organs, including the kidney, gonads, heart and nervous system. This is followed by a discussion of our current understanding of the molecular mechanisms by which WT1 and its two major isoforms regulate these processes at the transcriptional and post-transcriptional levels.

KEYWORDS:

Developmental disorders; Homeostasis; Molecular mechanisms of disease; WT1

PMID:
28811308
DOI:
10.1242/dev.153163
[Indexed for MEDLINE]
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