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J Cardiovasc Transl Res. 2017 Dec;10(5-6):489-498. doi: 10.1007/s12265-017-9766-9. Epub 2017 Aug 14.

Exploring the Biological and Mechanical Properties of Abdominal Aortic Aneurysms Using USPIO MRI and Peak Tissue Stress: A Combined Clinical and Finite Element Study.

Author information

1
Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK. noel.conlisk@ed.ac.uk.
2
School of Clinical Sciences, The University of Edinburgh, Edinburgh, UK. noel.conlisk@ed.ac.uk.
3
Institute for Bioengineering, The University of Edinburgh, Faraday Building, The King's Buildings, Mayfield Road, Edinburgh, EH9 3JL, UK. noel.conlisk@ed.ac.uk.
4
Centre for Cardiovascular Science, The University of Edinburgh, Edinburgh, UK.
5
School of Clinical Sciences, The University of Edinburgh, Edinburgh, UK.
6
Clinical Research Imaging Centre, The University of Edinburgh, Edinburgh, UK.
7
Vascular Engineering Laboratory, Harry Perkins Institute of Medical Research, Perth, Australia.
8
School of Mechanical and Chemical Engineering, The University of Western Australia, Perth, Australia.
9
Centre for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, UK.
10
Institute for Bioengineering, The University of Edinburgh, Faraday Building, The King's Buildings, Mayfield Road, Edinburgh, EH9 3JL, UK.

Abstract

Inflammation detected through the uptake of ultrasmall superparamagnetic particles of iron oxide (USPIO) on magnetic resonance imaging (MRI) and finite element (FE) modelling of tissue stress both hold potential in the assessment of abdominal aortic aneurysm (AAA) rupture risk. This study aimed to examine the spatial relationship between these two biomarkers. Patients (n = 50) > 40 years with AAA maximum diameters > = 40 mm underwent USPIO-enhanced MRI and computed tomography angiogram (CTA). USPIO uptake was compared with wall stress predictions from CTA-based patient-specific FE models of each aneurysm. Elevated stress was commonly observed in areas vulnerable to rupture (e.g. posterior wall and shoulder). Only 16% of aneurysms exhibited co-localisation of elevated stress and mural USPIO enhancement. Globally, no correlation was observed between stress and other measures of USPIO uptake (i.e. mean or peak). It is suggested that cellular inflammation and stress may represent different but complimentary aspects of AAA disease progression.

KEYWORDS:

Abdominal aortic aneurysms; Finite element analysis; MRI; Patient-specific modelling; USPIO uptake

PMID:
28808955
PMCID:
PMC5722953
DOI:
10.1007/s12265-017-9766-9
[Indexed for MEDLINE]
Free PMC Article

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