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Australas Phys Eng Sci Med. 2017 Sep;40(3):695-705. doi: 10.1007/s13246-017-0579-6. Epub 2017 Aug 14.

Measurement of dose in radionuclide therapy by using Cerenkov radiation.

Author information

1
Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, 29 Yudao St., Nanjing, 210016, China.
2
Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, 29 Yudao St., Nanjing, 210016, China. tangxiaobin@nuaa.edu.cn.
3
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 29 Yudao St., Nanjing, 210016, China. tangxiaobin@nuaa.edu.cn.
4
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, 29 Yudao St., Nanjing, 210016, China.

Abstract

This work aims to determine the relationship between Cerenkov photon emission and radiation dose from internal radionuclide irradiation. Water and thyroid phantoms were used to simulate the distribution of Cerenkov photon emission and dose deposition through Monte Carlo method. The relationship between Cerenkov photon emission and dose deposition was quantitatively analyzed. A neck phantom was also used to verify Cerenkov photon detection for thyroid radionuclide therapy. Results show that Cerenkov photon emission and dose deposition exhibit the same distribution pattern in water phantom, and this relative distribution relationship also existed in the thyroid phantom. Moreover, Cerenkov photon emission exhibits a specific quantitative relation to dose deposition. For thyroid radionuclide therapy, only a part of Cerenkov photon produced by thyroid could penetrate the body for detection; therefore, the use of Cerenkov radiation for measurement of radionuclide therapy dose may be more suitable for superficial tumors. This study demonstrated that Cerenkov radiation has the potential to be used for measuring radiation dose for radionuclide therapy.

KEYWORDS:

Cerenkov radiation; Dosimetry; Internal radiation; Radionuclide therapy

PMID:
28808904
DOI:
10.1007/s13246-017-0579-6
[Indexed for MEDLINE]

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