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Vaccine. 2017 Sep 12;35(38):5095-5101. doi: 10.1016/j.vaccine.2017.07.095. Epub 2017 Aug 12.

Benefits of flu vaccination for persons with diabetes mellitus: A review.

Author information

1
Institute for Tropical Diseases, Havenziekenhuis, Rotterdam, The Netherlands; Erasmus Medical Centre, Department of Viroscience, Rotterdam, The Netherlands; European Scientific Working Group on Influenza (ESWI), Belgium.
2
Maxima Medical Centre, Eindhoven, The Netherlands; Maastricht University Medical Centre, Maastricht, The Netherlands.
3
Institute for Tropical Diseases, Havenziekenhuis, Rotterdam, The Netherlands.
4
Department of Endocrinology, UZ Leuven, Leuven, Belgium.
5
Erasmus Medical Centre, Department of Viroscience, Rotterdam, The Netherlands; Artemis One Health Research Foundation, Utrecht, The Netherlands.
6
European Scientific Working Group on Influenza (ESWI), Belgium; Artemis One Health Research Foundation, Utrecht, The Netherlands; Research Institute for Emerging Infections and Zoonoses, Veterinary University Hannover, Germany. Electronic address: albert.osterhaus@tiho-hannover.de.

Abstract

Diabetes mellitus imposes a significant and increasing burden on society, with major consequences for human health, welfare and the economy worldwide. Persons with diabetes mellitus are at increased risk of developing severe complications after influenza virus infection and guidelines advise vaccination. The present evidence for influenza vaccine effectiveness in persons with diabetes mellitus is mainly based on observational studies with clinical endpoints like hospitalization and death, indicating a beneficial reduction of morbidity and mortality. Further supportive evidence comes from serological studies, in which persons with diabetes mellitus usually develop similar antibody levels after vaccination as healthy people. Observational studies may be prone to selection bias, and serological studies may not completely mirror vaccine effectiveness in the field. Although more controlled trials in persons with diabetes mellitus with laboratory-confirmed, influenza-specific outcomes would be desirable to better estimate the effect of vaccination, the currently available data justify routine influenza vaccination in persons with diabetes mellitus. As in this risk group, the use of influenza vaccine is far below target worldwide, efforts should be made to increase vaccination coverage.

KEYWORDS:

Diabetes; Efficacy; Influenza; Risk group; Safety; Vaccine effectiveness

PMID:
28807608
DOI:
10.1016/j.vaccine.2017.07.095
[Indexed for MEDLINE]

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