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Kidney Int. 2017 Sep;92(3):540-543. doi: 10.1016/j.kint.2017.04.012.

Is osteocyte Klotho bad for bone health?

Author information

1
Medicine master's degree program, Universidade Nove de Julho, UNINOVE, São Paulo, Brazil; Nephrology Division, Universidade de São Paulo, São Paulo, Brazil. Electronic address: rosa.moyses@uol.com.br.
2
Bone and Mineral Research Unit, Hospital Universitario Central de Asturias, Oviedo, Spain.

Abstract

The recent identification of αKlotho protein (Klotho) in osteocytes led to the generation of an experimental mouse model with osteocyte-specific Klotho ablation. This enabled Komaba et al. to assess the contribution to bone structure and function of osteocyte Klotho per se as compared with that of the systemic fibroblast growth factor 23-Klotho axis. Surprisingly, unlike the osteopenia and low bone turnover of systemic Klotho deletion, osteocyte-specific Klotho ablation resulted in increased osteoblastic activity and bone formation rate.

PMID:
28807259
DOI:
10.1016/j.kint.2017.04.012

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