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Chin J Nat Med. 2017 Jul;15(7):546-549. doi: 10.1016/S1875-5364(17)30081-X.

Tagetones A and B, new cytotoxic monocyclic diterpenoids from flowers of Tagetes minuta.

Author information

1
Department of Pharmacognosy and Pharmaceutical Chemistry, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah 30078, Saudi Arabia. Electronic address: sabrinshaur@gmail.com.
2
Department of Natural Products and Alternative Medicine, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Abstract

Tagetones A (1) and B (2), two new monocyclic diterpenoids were isolated from the n-hexane fraction of fresh flowers of Tagetes minuta L. (Asteraceae). Their structures were established by multiple spectroscopic methods (IR, HR-ESI-MS, and 1D-, and 2D-NMR), in addition to comparison with literature data. Compound 1 showed cytotoxic activity towards MCF7 and A549 cancer cells with IC50 values being 4.68 and 4.24 µmol·L-1, respectively, compared to doxorubicin (IC50 0.13 and 1.12 µmol·L-1, respectively). Compound 2 also exhibited significant activity against HCT116 cancer cells (IC50, 6.30 µmol·L-1).

KEYWORDS:

Asteraceae; Cytotoxic; Monocyclic diterpenoids; Tagetes minuta; Tagetones

PMID:
28807229
DOI:
10.1016/S1875-5364(17)30081-X
[Indexed for MEDLINE]

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