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PLoS One. 2017 Aug 14;12(8):e0182295. doi: 10.1371/journal.pone.0182295. eCollection 2017.

Sublingual immunotherapy (SLIT) for house dust mites does not prevent new allergen sensitization and bronchial hyper-responsiveness in allergic rhinitis children.

Author information

1
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Korea.
2
Department of Otorhinolaryngology-Head and Neck Surgery, Korea University College of Medicine, Korea University Ansan Hospital, Ansan, Korea.
3
Department of Otorhinolaryngology-Head and Neck Surgery, Bundang Jesaeng General Hospital, Deajin Medical Center, Seongnam, Korea.
4
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
5
Department of Biomedical Science, Seoul National University Graduate School, Seoul, Korea.
6
Cancer Research Institute, Seoul National University, Seoul, Korea.
7
Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.
8
Institute of Allergy and Clinical Immunology, Seoul National University Medical Research Center, Seoul, Korea.
9
Sensory Organ Research Center, Seoul National University Medical Research Center, Seoul, Korea.

Abstract

INTRODUCTION:

The aim of this study is to identify the effects of sublingual immunotherapy (SLIT) on immunologic parameters and bronchial-hyper-responsiveness in children with allergic rhinitis to house-dust mite (HDM), through long-term follow-up cohort.

METHODS:

Among the Allergic Rhinitis Cohort Study for Kids, pediatric patients who visited the hospital for rhinitis symptoms and proven allergy to HDM through skin prick test were studied. In this cohort, 37 patients received SLIT more than 3-years (SLIT group), and 184 patients received only pharmacologic therapy (non-SLIT group) were included in this study. The results of skin prick test, eosinophil percent and count, total immunoglobulin E (IgE), and bronchial provocation test at initial and 3-year followed-up were compared in the two groups.

RESULTS:

After 3 year follow-up, only the serum eosinophil percent decreased more significantly in SLIT group than that in the non-SLIT group. New-sensitization rate other than HDM between SLIT and non-SLIT group did not show any significant differences. The distribution of sensitized allergen other than HDM showed increasing tendency after 3 years in both groups. Older age and a small number of sensitized allergen affected the improvement of bronchial hyper-responsiveness regardless of SLIT.

CONCLUSION:

HDM SLIT in allergic rhinitis children for 3 years in Korea does not affect prevention of new sensitization and poly-sensitization rate increment, and improvement of bronchial hyper-responsiveness.

PMID:
28806766
PMCID:
PMC5555666
DOI:
10.1371/journal.pone.0182295
[Indexed for MEDLINE]
Free PMC Article

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