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Sci Total Environ. 2018 Jan 1;610-611:291-297. doi: 10.1016/j.scitotenv.2017.08.057. Epub 2017 Aug 11.

Parental exposure to bisphenol A and its analogs influences zebrafish offspring immunity.

Author information

1
Institute of Environmental Health and Ecological Security, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China.
2
Freshwater Fisheries Research Center, Chinese Academy of Fishery Sciences, Wuxi 214081, China; Key Laboratory of Fishery Eco-environment Assessment and Resource Conservation in Middle and Lower Reaches of the Yangtze River, CAFS, Wuxi 214081, China.
3
School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, China.
4
School of Chemistry & Chemical Engineering, Jiangsu University, Zhenjiang 212013, China.
5
Institute of Environmental Health and Ecological Security, School of Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China. Electronic address: xuhai@ujs.edu.cn.

Abstract

Transgenerational effects of environmental pollutants on humans and animals are complex. Thus, we used zebrafish to evaluate the effects of parental whole-life cycle exposure to bisphenol A and its analogs (bisphenol S and F) on offspring innate immunity. At adulthood, offspring were examined with/without continued chemicals treatment until 72h post-fertilization (hpf). To measure offspring immune function, larvae at 72 hpf were expose for 24h with/without the viral mimic polyinosinic-cytidylic acid (Poly I:C) or the bacterial mimic Pam3Cys-Ser-Lys4 (PAM3CSK4). Data show modified immunity in offspring. Specifically, lysozyme activity was significantly induced in F1 larvae and respiratory burst response and oxidative defense genes were inhibited. Genes of the innate immune system including Toll-like receptors and their downstream molecules and inflammatory cytokines were significantly down-regulated, whereas matrix metalloproteinases were up-regulated in larvae. In addition, recombination-activating genes in the immature adaptive immune system were significantly reduced. Thus, immune defense is diminished by exposing parental generations of zebrafish to environmentally relevant concentration of bisphenols and this suggests that fish chronically exposed to bisphenols in the wild may be vulnerable to pathogens.

PMID:
28806546
DOI:
10.1016/j.scitotenv.2017.08.057
[Indexed for MEDLINE]

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