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Otol Neurotol. 2017 Sep;38(8):e224-e231. doi: 10.1097/MAO.0000000000001439.

NANOCI-Nanotechnology Based Cochlear Implant With Gapless Interface to Auditory Neurons.

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*University Department of ORL, Head & Neck Surgery, Inselspital †Department of Clinical Research, University of Bern, Bern, Switzerland ‡Department of Otorhinolaryngology-Head & Neck Surgery, University of Tübingen, Tübingen, Germany §Department of Surgical Sciences, Section of ORL, Uppsala University, Uppsala, Sweden ||Hearing and Balance Research Unit, Department of Otorhinolaryngology and The Finnish Centre for Alternative Methods, University of Tampere, Tampere, Finland ¶Haute Ecole Arc Ingénierie, HES-SO - University of Applied Sciences Western Switzerland, La Chaux-de-Fonds #Department of Chemistry, The Center for Advanced Materials and Nanotechnology and The Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel **EMC Microcollections GmbH, Tübingen, Germany ††MED-EL GmbH, Worldwide Headquarters, Innsbruck, Austria ‡‡SCIPROM Sàrl, Rue du Centre 70, St-Sulpice §§Department of Clinical Neurosciences, Service of ORL and HNS, HUG, University Hospital of Geneva, Geneva, Switzerland.


: Cochlear implants (CI) restore functional hearing in the majority of deaf patients. Despite the tremendous success of these devices, some limitations remain. The bottleneck for optimal electrical stimulation with CI is caused by the anatomical gap between the electrode array and the auditory neurons in the inner ear. As a consequence, current devices are limited through 1) low frequency resolution, hence sub-optimal sound quality and 2), large stimulation currents, hence high energy consumption (responsible for significant battery costs and for impeding the development of fully implantable systems). A recently completed, multinational and interdisciplinary project called NANOCI aimed at overcoming current limitations by creating a gapless interface between auditory nerve fibers and the cochlear implant electrode array. This ambitious goal was achieved in vivo by neurotrophin-induced attraction of neurites through an intracochlear gel-nanomatrix onto a modified nanoCI electrode array located in the scala tympani of deafened guinea pigs. Functionally, the gapless interface led to lower stimulation thresholds and a larger dynamic range in vivo, and to reduced stimulation energy requirement (up to fivefold) in an in vitro model using auditory neurons cultured on multi-electrode arrays. In conclusion, the NANOCI project yielded proof of concept that a gapless interface between auditory neurons and cochlear implant electrode arrays is feasible. These findings may be of relevance for the development of future CI systems with better sound quality and performance and lower energy consumption. The present overview/review paper summarizes the NANOCI project history and highlights achievements of the individual work packages.

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