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Nat Rev Immunol. 2017 Nov;17(11):665-678. doi: 10.1038/nri.2017.86. Epub 2017 Aug 14.

Innate lymphoid cells: major players in inflammatory diseases.

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Aix Marseille Université, CNRS, INSERM, Centre d'Immunologie de Marseille-Luminy, Marseille, France.
APHM, Hôpital de la Timone, Service de Médecine Interne, Marseille, France.
APHM, Hôpital de la Timone, Service d'Immunologie-Marseille Immunopôle, Marseille, France.


Recent years have seen a marked increase in our understanding of innate lymphoid cells (ILCs). ILCs can be classified into different groups based on their similarity to T cell subsets in terms of their expression of key transcription factors and cytokine production. Various immunological functions of ILCs have been described, and increasing numbers of studies have implicated these cells in inflammatory disorders. Here, we detail the roles of ILCs in inflammatory diseases; we cover type 2 inflammatory diseases (such as asthma, chronic rhinosinusitis and atopic dermatitis), as well as inflammatory bowel diseases, psoriasis and other systemic or organ-specific inflammatory and autoimmune diseases. Future directions in the field are discussed, together with potential avenues of treatment.

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