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Semin Cell Dev Biol. 2018 Jun;78:13-21. doi: 10.1016/j.semcdb.2017.08.009. Epub 2017 Aug 11.

Exosomes in cancer: Use them or target them?

Author information

1
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal (i3S), Porto, Portugal; Institute of Molecular Pathology & Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
2
Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Portugal (i3S), Porto, Portugal; Institute of Molecular Pathology & Immunology of the University of Porto (IPATIMUP), Porto, Portugal; Medical Faculty of the University of Porto (FMUP), Portugal. Electronic address: smelo@ipatimup.pt.

Abstract

Exosomes are small extracellular vesicles with a significant role in most processes associated with cancer. On one hand, exosomes role in the different hallmarks of cancer has been widely described, highlighting the urge to understand the potential to target communication mediated by exosomes as a novel therapeutic approach in cancer. On the other hand, exosomes stability in circulation and tumor-targeting capacity shows their applicability in the delivery of anti-cancer molecules. This review will discuss the dual applicability of exosomes in cancer focusing on their usage for therapy improvement, or their targeting to block their supportive role in tumor progression and response to therapy. We highlight the current developments and the strategies used to enhance the potential of exosomes to become clinical partners in the treatment of cancer.

KEYWORDS:

Cancer; Exosomes; Extracellular vesicles; Therapy

PMID:
28803894
DOI:
10.1016/j.semcdb.2017.08.009
[Indexed for MEDLINE]

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