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Heart Lung. 2017 Sep - Oct;46(5):375-381. doi: 10.1016/j.hrtlng.2017.06.001. Epub 2017 Aug 10.

The Yale Fitness Intervention Trial in female cancer survivors: Cardiovascular and physiological outcomes.

Author information

1
Yale University School of Nursing, USA. Electronic address: Tish.knobf@yale.edu.
2
Yale University School of Nursing, USA. Electronic address: Sangchoon.jeon@yale.edu.
3
Michigan State University, USA. Electronic address: Barbara.smith@hc.msu.edu.
4
National Institutes of Health, USA. Electronic address: Lyndsay.harris@nih.gov.
5
Yale University School of Medicine, USA. Electronic address: Siobhan.thompson@yale.edu.
6
Yale University School of Medicine, USA. Electronic address: Mitch.stacey@yale.edu.
7
Yale University School of Medicine, USA. Electronic address: Karl.insogna@yale.edu.
8
Yale University School of Medicine, USA. Electronic address: Albert.sinusas@yale.edu.

Abstract

BACKGROUND:

Induced premature menopause and cardio-toxic therapy increase cardiovascular disease risk in female cancer survivors.

OBJECTIVE:

To compare the effects of a 12 month aerobic-resistance fitness center intervention to home based physical activity on cardiovascular function and metabolic risk factors.

METHODS:

Subjects (N = 154) who had completed primary and/or adjuvant chemotherapy (past 3 years) were randomized to a fitness center intervention or a home based group. The fitness center intervention was a structured thrice weekly aerobic (30 min brisk walking treadmill in target heart range) combined with resistance (30 min of lower body strength training) exercise program, supervised for the first 6 months. The home based group received national guidelines for 30 min moderate intensity exercise most days of the week. Fasting serum samples were collected at baseline, 6 and 12 months for insulin, glucose, lipids and hemoglobin A-1C. A graded exercise stress test was also performed at baseline and 6 months.

RESULTS:

The majority of subjects were white (85.7%), had breast cancer (83.1%) and the average age was 51.9 years. Subjects in the fitness center intervention had significantly improved time on treadmill (p = .039), improved heart rate recovery at 1 min (p = .028), greater MET minutes/week (p ≤ .0001), a trend for improved insulin resistance (p = .067) and stable insulin levels (p = .045) compared to the home based physical activity group.

CONCLUSIONS:

Exercise represents a potential cardiac risk reduction intervention for cancer survivors. CLINICAL TRIALS.GOV: NCT01102985.

KEYWORDS:

Breast cancer; Cardiovascular fitness; Exercise; Heart rate recovery; Insulin resistance

PMID:
28803675
PMCID:
PMC6129386
DOI:
10.1016/j.hrtlng.2017.06.001
[Indexed for MEDLINE]
Free PMC Article

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