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Trends Biochem Sci. 2017 Sep;42(9):686-689. doi: 10.1016/j.tibs.2017.07.003. Epub 2017 Aug 8.

The Ribosome Holds the RNA Polymerase on Track in Bacteria.

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Centre for Integrative Biology (CBI), Department of Integrated Structural Biology, IGBMC (Institute of Genetics and of Molecular and Cellular Biology), 1 rue Laurent Fries, Illkirch, France; Centre National de la Recherche Scientifique (CNRS) UMR 7104, Illkirch, France; Institut National de la Santé et de la Recherche Médicale (INSERM) U964, Illkirch, France; Université de Strasbourg, Strasbourg, France. Electronic address:


The central dogma of molecular biology comprises two fundamental mechanistic steps of gene expression (transcription and translation), which, in bacteria, are coupled. A recent study provides structural insights into a supercomplex between the RNA polymerase and the ribosome, thus highlighting the synergy between two key macromolecular machineries in the cell.


RNA polymerase; bacteria; gene expression; ribosome; transcription; translation

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