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Biomed Pharmacother. 2017 Oct;94:742-746. doi: 10.1016/j.biopha.2017.07.135. Epub 2017 Aug 8.

Hypoglycemic and hypolipidemic effects of aqueous extract of phaseolus vulgaris pods in streptozotocin-diabetic rats.

Author information

1
College of Medicine, King Faisal University, Alahsaa, Saudi Arabia. Electronic address: al.muaigel@hotmail.com.
2
Department of Biochemistry, College of Medicine, King Faisal University, Alahsaa, Saudi Arabia.
3
College of Medicine, King Faisal University, Alahsaa, Saudi Arabia.

Abstract

The present investigation was carried out to evaluate the reduction potential of aqueous extract of casing of pods of phaseolus vulgaris in blood glucose and lipids levels among hyperglycemic streptozotocin (STZ)-induced rats. Oral administration of 150mg/kg of aqueous oral administration of aqueous pod extract of phaseolus vulgaris to diabetic rats for 40days resulted in a significant decrease in blood glucose (p<001), cholesterol (P<0.01) and triglycerides (P<0.01). In addition, glibenclamide reduced blood glucose, cholesterol and triglycerides. It is concluded that both aqueous extract of casing of pods of phaseolus vulgaris and glibenclamide reduced the blood levels of glucose and lipids. In addition, aqueous extract of phaseolus vulgaris pods was more effective than glibenclamide in reducing blood glucose.

KEYWORDS:

Diabetes; Hypoglycemic; Hypolipidemic; Phaseolus vulgaris pods; Saudi Arabia

PMID:
28800543
DOI:
10.1016/j.biopha.2017.07.135
[Indexed for MEDLINE]

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