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J Alzheimers Dis. 2017;60(1):323-332. doi: 10.3233/JAD-170014.

Effects of Exercise on Cognitive Function in Older People with Dementia: A Randomized Controlled Trial.

Author information

1
Department of Community Medicine and Rehabilitation, Physiotherapy, Umeå University, Umeå, Sweden.
2
Department of Community Medicine and Rehabilitation, Geriatric Medicine, Umeå University, Umeå, Sweden.
3
Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden.

Abstract

BACKGROUND:

Although physical exercise has been suggested to influence cognitive function, previous exercise studies show inconsistent results in people with dementia.

OBJECTIVES:

To investigate effects of exercise on cognitive function in people with dementia.

METHOD:

The Umeå Dementia and Exercise (UMDEX) study, a cluster-randomized controlled trial, was set in 16 nursing homes in Umeå, Sweden. One hundred-and-forty-one women and 45 men with dementia; mean age of 85 y and mean Mini-Mental State Examination (MMSE) score of 15, were randomized to a High-Intensity Functional Exercise program or a seated attention control activity. Blinded assessors measured global cognitive function using the MMSE and the Alzheimer's disease Assessment Scale - Cognitive subscale (ADAS-Cog), and executive function using Verbal fluency (VF) at baseline and 4 months (directly after intervention completion), and MMSE and VF at 7 months.

RESULTS:

Linear mixed models showed no between-group effects in mean difference from baseline (95% confidence intervals, CI) at 4 months in MMSE (-0.27; 95% CI -1.4 to 0.87, p = 0.644), ADAS-Cog (-1.04, 95% CI -4 to 1.92, p = 0.491), or VF (-0.53, 95% CI -1.42 to 0.35, p = 0.241) or at 7 months in MMSE (-1.15, 95% CI -2.32 to 0.03, p = 0.056) or VF (-0.18, 95% CI -1.09 to 0.74, p = 0.707).

CONCLUSION:

A 4-month, high-intensity functional exercise program had no superior effects on global cognition or executive function in people with dementia living in nursing homes when compared with an attention control activity.

KEYWORDS:

Cognition; dementia; exercise; residential facilities

PMID:
28800328
PMCID:
PMC5611799
DOI:
10.3233/JAD-170014
[Indexed for MEDLINE]
Free PMC Article

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