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Environ Sci Pollut Res Int. 2017 Oct;24(28):22241-22250. doi: 10.1007/s11356-017-9880-x. Epub 2017 Aug 10.

Dissipation kinetics, pre-harvest residue limits, and hazard quotient assessments of pesticides flubendiamide and fluopicolide in Korean melon (Cucumis melo L. var. makuwa) grown under regulated conditions in plastic greenhouses.

Author information

1
Natural Products Chemistry Laboratory, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea.
2
Department of Pharmacology, Faculty of Veterinary Medicine, Cairo University, Giza, 12211, Egypt. abdelaty44@hotmail.com.
3
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Seoul, 143-701, Republic of Korea. abdelaty44@hotmail.com.
4
Food Safety Division, Ministry of Food and Drug Safety, Osongsaengmeyong 2-ro, Osongeup, Heungdeok-gu, Cheongju, Chungcheongbuk-do, 28159, Republic of Korea.
5
Department of Pharmacology, College of Medicine, Chung-Ang University, 221, Heuksuk-dong, Dongjak-gu, Seoul, 156-756, Republic of Korea.
6
Department of Veterinary Anatomy, College of Veterinary Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
7
Department of Veterinary Pharmacology and Toxicology, College of Veterinary Medicine, Konkuk University, Seoul, 143-701, Republic of Korea.
8
Natural Products Chemistry Laboratory, College of Agriculture and Life Sciences, Chonnam National University, Gwangju, 500-757, Republic of Korea. jhshim@jnu.ac.kr.

Abstract

The dissipation kinetics, pre-harvest residue limits, and hazard quotient (HQ) assessments of the pesticides flubendiamide and fluopicolide were conducted for Korean melon (Cucumis melo L. var. makuwa) cultivated at two different sites. A single extraction and cleanup procedure was carried out using acetone (partitioned with dichloromethane) and amino solid-phase extraction cartridges, respectively. Residue analysis was performed by HPLC with ultraviolet detection. Both pesticides showed excellent linearity with correlation coefficients of 0.9999 and 0.9996 for flubendiamide and fluopicolide, respectively. The accuracy (expressed as recovery %) at three spiking levels was 92.0-103.6 and 82.8-105.3%, and the precision (expressed as relative standard deviation) was 1.7-3.4 and 2.7-5.3% for flubendiamide and fluopicolide, respectively. The initial residues of flubendiamide/fluopicolide were 0.326/0.376 and 0.206/0.298 mg/kg at sites 1 and 2, respectively. These amounts were substantially lower than the maximum residue limits (MRLs = 1 and 0.5 mg/kg for flubendiamide and fluopicolide, respectively) established by the Korean Ministry of Food and Drug Safety. The half-lives of flubendiamide were 5.8 and 6.5 days, and those of fluopicolide were 6.7 and 9.1 days at sites 1 and 2, respectively. The shorter half-lives were attributed to seasonal variations (higher temperatures) and enzymatic and metabolic profiling. The risk assessment HQs of flubendiamide were 0.217/0.249 on day 0, which decreased to 0.102/0.168 on day 5, and to 0.065/0.88 on day 10; the HQ values for fluopicolide were 0.029/0.042, 0.022/0.025, and 0.010/0.019 on day 0, day 5, and day 10, for sites 1/2, respectively. From this data, we concluded that the fruits could be consumed safely.

KEYWORDS:

Dissipation pattern; Flubendiamide; Fluopicolide; Hazard quotient; Korean melon; PHRL

PMID:
28799066
DOI:
10.1007/s11356-017-9880-x
[Indexed for MEDLINE]

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