Format

Send to

Choose Destination
Int J MCH AIDS. 2017;6(1):27-35. doi: 10.21106/ijma.164.

HIV-Positive Women Taking Lifelong Antiretroviral Therapy Report Better Adherence Than Women Taking Short-Course Prophylaxis During and After Pregnancy Under PMTCT Program Option A in Lusaka, Zambia.

Author information

1
Department of Community and Behavioral Health, University of Colorado School of Public Health, Aurora, CO 80045, USA.
2
Department of Pediatrics, University of Colorado School of Medicine and Children's Hospital Colorado, Aurora, CO 80045, USA.
3
Center for Global Health, University of Colorado School of Medicine, School of Public Health, Aurora, CO 80045, USA.
4
Department of Obstetrics and Gynecology, University Teaching Hospital, Lusaka, Zambia.

Abstract

BACKGROUND AND OBJECTIVES:

HIV-positive women's adherence to antiretrovirals is critical for prevention of mother-to-child transmission. We aimed to establish if mothers taking triple lifelong antiretroviral therapy report higher adherence compared to mothers taking short-course prophylaxis under Option A in Lusaka, Zambia.

METHODS:

In this clinic-based cross-sectional study, we interviewed 320 HIV-positive mothers at a large public health facility in Lusaka in 2014. Participants reported adherence using a visual analog scale. Multiple logistic regression models were used to determine the adjusted odds of adherence by mother's prescribed regimen.

RESULTS:

Women taking lifelong triple antiretroviral therapy report higher adjusted odds of adherence during pregnancy, postpartum, and to giving the infant prophylaxis compared to women to women taking short-course prophylaxis.

DISCUSSION:

Women on lifelong therapy may have better adherence compared to women on short course prophylaxis because they knew their positive status for longer or were symptomatic with HIV-related disease. The lifelong therapy regimen may be easier for women to follow, particularly because they are required to give the infant prophylaxis for a shorter duration of time.

CONCLUSIONS AND GLOBAL HEALTH IMPLICATIONS:

Our results indicate that lifelong triple antiretroviral therapy has the potential to promote better drug adherence during and after pregnancy among women living with HIV in sub-Saharan Africa, compared to short-course antiretroviral regimens.

KEYWORDS:

ART; Adherence; Antiretroviral Therapy; HIV-positive Women; Option A; PMTCT; Prevention of Mother-to-Child Transmission; Zambia

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center