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Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L733-L740. doi: 10.1152/ajplung.00139.2017. Epub 2017 Aug 10.

LungMAP: The Molecular Atlas of Lung Development Program.

Author information

1
RTI International, Research Triangle Park, North Carolina.
2
RTI International, Research Triangle Park, North Carolina; rclark@rti.org.
3
Pacific Northwest National Laboratory, Richland, Washington.
4
Texas Advanced Computing Center, Austin, Texas.
5
University of Washington, Seattle, Washington.
6
University of California, San Diego, California.
7
Yale School of Medicine, New Haven, Connecticut.
8
University of Rochester Medical Center, Rochester, New York.
9
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
10
Children's Hospital of Los Angeles, Los Angeles, California.
11
Duke University School of Medicine, Durham, North Carolina; and.
12
University of Alabama, Birmingham, Alabama.

Abstract

The National Heart, Lung, and Blood Institute is funding an effort to create a molecular atlas of the developing lung (LungMAP) to serve as a research resource and public education tool. The lung is a complex organ with lengthy development time driven by interactive gene networks and dynamic cross talk among multiple cell types to control and coordinate lineage specification, cell proliferation, differentiation, migration, morphogenesis, and injury repair. A better understanding of the processes that regulate lung development, particularly alveologenesis, will have a significant impact on survival rates for premature infants born with incomplete lung development and will facilitate lung injury repair and regeneration in adults. A consortium of four research centers, a data coordinating center, and a human tissue repository provides high-quality molecular data of developing human and mouse lungs. LungMAP includes mouse and human data for cross correlation of developmental processes across species. LungMAP is generating foundational data and analysis, creating a web portal for presentation of results and public sharing of data sets, establishing a repository of young human lung tissues obtained through organ donor organizations, and developing a comprehensive lung ontology that incorporates the latest findings of the consortium. The LungMAP website (www.lungmap.net) currently contains more than 6,000 high-resolution lung images and transcriptomic, proteomic, and lipidomic human and mouse data and provides scientific information to stimulate interest in research careers for young audiences. This paper presents a brief description of research conducted by the consortium, database, and portal development and upcoming features that will enhance the LungMAP experience for a community of users.

KEYWORDS:

3D imaging; lung development; lung imaging; lung omics; single cell analysis; web resource

PMID:
28798251
PMCID:
PMC5792185
DOI:
10.1152/ajplung.00139.2017
[Indexed for MEDLINE]
Free PMC Article

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