Format

Send to

Choose Destination
J Appl Physiol (1985). 2017 Nov 1;123(5):1303-1320. doi: 10.1152/japplphysiol.00101.2017. Epub 2017 Aug 10.

The hypoxia-adenosine link during inflammation.

Author information

1
Department of Anesthesiology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas jessica.l.bowser@uth.tmc.edu.
2
Department of Anesthesiology, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, Texas.

Abstract

Hypoxic tissue conditions occur during a number of inflammatory diseases and are associated with the breakdown of barriers and induction of proinflammatory responses. At the same time, hypoxia is also known to induce several adaptive and tissue-protective pathways that dampen inflammation and protect tissue integrity. Hypoxia-inducible factors (HIFs) that are stabilized during inflammatory or hypoxic conditions are at the center of mediating these responses. In the past decade, several genes regulating extracellular adenosine metabolism and signaling have been identified as being direct targets of HIFs. Here, we discuss the relationship between inflammation, hypoxia, and adenosine and that HIF-driven adenosine metabolism and signaling is essential in providing tissue protection during inflammatory conditions, including myocardial injury, inflammatory bowel disease, and acute lung injury. We also discuss how the hypoxia-adenosine link can be targeted therapeutically in patients as a future treatment approach for inflammatory diseases.

KEYWORDS:

HIF; acute lung injury; adenosine; adenosine receptors; hypoxia; inflammation; inflammatory bowel disease; myocardial injury

PMID:
28798196
PMCID:
PMC5792095
DOI:
10.1152/japplphysiol.00101.2017
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center