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Gen Comp Endocrinol. 1986 Dec;64(3):435-9.

Cardiovascular effects of urotensin II in anesthetized and pithed rats.


Gillichthys urotensin II (GUII; 1.5-150 nmol kg-1) reduced blood pressure in anesthetized rats, diastolic pressure being reduced to a greater extent than systolic. The effect was slow in onset (peak at 4-5 min) and longlasting (up to 60 min), and was accompanied by a reflex tachycardia. The hypotension was not blocked by propranolol or by mepyramine. In pithed rats, GUII (150 nmol kg-1) reduced the pressor responses to sympathetic nerve stimulation, noradrenaline, and Arg-vasopressin. Somatostatin (150 nmol kg-1) had no effect on the sympathetic pressor response but reduced heart rate. It is concluded that GUII is a vasodilator in the rat, an action not shared with somatostatin.

[Indexed for MEDLINE]

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