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Oral Oncol. 2017 Sep;72:38-47. doi: 10.1016/j.oraloncology.2017.07.003. Epub 2017 Jul 12.

Prognostic biomarkers in oral squamous cell carcinoma: A systematic review.

Author information

1
Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil; Department of Biomedical Sciences, Faculty of Health Sciences, University of Talca (UTALCA), Talca, Maule Region, Chile; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
2
Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil; Department of Oral Diagnosis, Piracicaba Dental School, University of Campinas (UNICAMP), Piracicaba, São Paulo, Brazil.
3
Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil.
4
Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil; Functional and Molecular Biology Graduate Program, Institute of Biology, University of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
5
Brazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, São Paulo, Brazil. Electronic address: adriana.paesleme@lnbio.cnpem.br.

Abstract

Over the years, several tumor biomarkers have been suggested to foresee the prognosis oral squamous cell carcinoma (OSCC) patients. Here, we present a systematic review to identify, evaluate and summarize the evidence for OSCC reported markers. Eligible studies were identified through a literature search of MEDLINE/PubMed until January 2016. We included primary articlesreporting overall survival, disease-free survival and cause-specific survival as outcomes. Our findings were analysed using REporting recommendations for tumor MARKer prognostic studies (REMARK), QuickGo tool and SciCurve trends. We found 41 biomarkers, mostly proteins evaluated by immunohistochemistry. The selected studies are of good quality, although, any study referred to a sample size determination. Considering the lack of follow-up studies, the molecules are still potential biomarkers. Further research is required to validate these biomarkers in well-designed clinical cohort-based studies.

KEYWORDS:

Biomarkers, tumor; Mouth neoplasms; Oral cancer; Oral squamous cell carcinoma; Review; Systematic

[Indexed for MEDLINE]

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