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Euro Surveill. 2017 Aug 3;22(31). pii: 30586. doi: 10.2807/1560-7917.ES.2017.22.31.30586.

Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015.

Author information

1
Laboratorio de Biología Molecular y Microbiología, Instituto Tecnológico Agrario de Castilla y León, Valladolid, Spain.
2
Departamento de Ingeniería Agrícola y Forestal, Tecnología de los Alimentos, Escuela Técnica Superior de Ingenierías Agrarias, Universidad de Valladolid, Palencia, Spain.
3
These authors contributed equally to the manuscript.
4
Departamento de Bioquímica, Biología Molecular y Genética, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
5
Área de Microbiología, Departamento de Biotecnología y Ciencia de los Alimentos, Universidad de Burgos, Burgos, Spain.
6
VISAVET Health Surveillance Centre, Universidad Complutense, Madrid, Spain.
7
MARE - Marine and Environmental Sciences Centre, Instituto Politécnico de Leiria, Peniche, Portugal.
8
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad de Extremadura, Cáceres, Spain.
9
Subdirección General de Sanidad e Higiene Animal y Trazabilidad, Ministerio de Agricultura y Pesca, Alimentación y Medio Ambiente, Madrid, Spain.
10
Laboratorio Central de Veterinaria, Ministerio de Agricultura y Pesca, Alimentación y Medio Ambiente, Algete, Spain.
11
Departamento de Sanidad Animal, Facultad de Veterinaria, Universidad Complutense, Madrid, Spain.
12
INBIO G+C, Universidad de Extremadura, Cáceres, Spain.

Abstract

Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States.

KEYWORDS:

Escherichia coli; antimicrobial resistance; bovine; cattle; colistin; mcr-1; mcr-3

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