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PLoS One. 2017 Aug 10;12(8):e0182596. doi: 10.1371/journal.pone.0182596. eCollection 2017.

Therapeutic response assessment using 3D ultrasound for hepatic metastasis from colorectal cancer: Application of a personalized, 3D-printed tumor model using CT images.

Author information

1
Department of Radiology, Boramae Medical Center, Seoul, Korea.
2
Department of Radiology, Seoul National University Hospital, Seoul, Korea.
3
Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea.
4
Cancer Research Institute, Seoul National University, Seoul, Korea.
5
Department of Radiology, National Cancer Center, Gyeonggi-do, Korea.

Abstract

BACKGROUND & AIMS:

To evaluate accuracy and reliability of three-dimensional ultrasound (3D US) for response evaluation of hepatic metastasis from colorectal cancer (CRC) using a personalized 3D-printed tumor model.

METHODS:

Twenty patients with liver metastasis from CRC who underwent baseline and after chemotherapy CT, were retrospectively included. Personalized 3D-printed tumor models using CT were fabricated. Two radiologists measured volume of each 3D printing model using 3D US. With CT as a reference, we compared difference between CT and US tumor volume. The response evaluation was based on Response Evaluation Criteria in Solid Tumors (RECIST) criteria.

RESULTS:

3D US tumor volume showed no significant difference from CT volume (7.18 ± 5.44 mL, 8.31 ± 6.32 mL vs 7.42 ± 5.76 mL in CT, p>0.05). 3D US provided a high correlation coefficient with CT (r = 0.953, r = 0.97) as well as a high inter-observer intraclass correlation (0.978; 0.958-0.988). Regarding response, 3D US was in agreement with CT in 17 and 18 out of 20 patients for observer 1 and 2 with excellent agreement (κ = 0.961).

CONCLUSIONS:

3D US tumor volume using a personalized 3D-printed model is an accurate and reliable method for the response evaluation in comparison with CT tumor volume.

PMID:
28797089
PMCID:
PMC5552302
DOI:
10.1371/journal.pone.0182596
[Indexed for MEDLINE]
Free PMC Article

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