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PLoS One. 2017 Aug 10;12(8):e0182321. doi: 10.1371/journal.pone.0182321. eCollection 2017.

The epidemiology of medically attended respiratory syncytial virus in older adults in the United States: A systematic review.

Author information

1
RTI Health Solutions, Research Triangle Park, North Carolina, United States.
2
Novavax, Gaithersburg, Maryland, United States.

Abstract

OBJECTIVE:

This review was undertaken to assess the historical evidence of the disease incidence and burden of laboratory-confirmed respiratory syncytial virus (RSV) in medically attended older adults.

DESIGN:

A qualitative systematic literature review was performed; no statistical synthesis of the data was planned, in anticipation of expected heterogeneity across studies in this population.

METHODS:

A literature search of PubMed, Embase, and the Cochrane Library was conducted for studies of medically attended RSV in older adults (≥ 50 years) published in the last 15 years. Two independent reviewers screened titles and abstracts based on predefined inclusion and exclusion criteria.

RESULTS:

From 10 studies reporting incidence proportions, RSV may be the causative agent in up to 12% of medically attended acute respiratory illness in older adults unselected for comorbidities, with variations in clinical setting and by year. In multiple studies, medically attended-RSV incidence among older adults not selected for having underlying health conditions increased with increasing age. Of prospectively followed lung transplant recipients, 16% tested positive for RSV. In hospitalized adults with chronic cardiopulmonary diseases, 8% to 13% were infected with RSV during winter seasons (8%-13%) or metapneumovirus season (8%). Hospitalizations for RSV in older adults typically lasted 3 to 6 days, with substantial proportions requiring intensive care unit admission and mechanical ventilation. Among older adults hospitalized with RSV, the mortality rate was 6% to 8%.

CONCLUSIONS:

Protection of older adults against RSV could reduce respiratory-related burden, especially as age increases and the prevalence of comorbidities (especially cardiopulmonary comorbidities) grows.

PMID:
28797053
PMCID:
PMC5552193
DOI:
10.1371/journal.pone.0182321
[Indexed for MEDLINE]
Free PMC Article

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