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Leuk Res Rep. 2017 Jul 27;8:7-10. doi: 10.1016/j.lrr.2017.07.002. eCollection 2017.

An unusual type of myeloid sarcoma localization following myelofibrosis: A case report and literature review.

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Hematology Division, IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, Milan, Italy.
Division of Pathology, Department of Pathophysiology and Transplantation, University of Milan, and IRCCS Ca' Granda - Maggiore Policlinico Hospital Foundation, Milan, Italy.


Myeloid Sarcoma (MS) is a rare malignancy that can present as an isolated disease or more frequently in association with or following acute myeloid leukemia or other myeloid neoplasms and rarely following myelofibrosis. Since molecular pathogenesis and prognostic factors of MS are not well understood, its prognosis remains poor even in the era of novel agents and target therapies. We report the case of a patient with MS following myelofibrosis with multiple subcutaneous, cutaneous and muscle localizations; the latter has been reported in the literature as anecdotal. In this way we aimed to enhance the understanding of this disease.


Calreticulin; Myeloid sarcoma; Primary myelofibrosis

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