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Planta Med. 2018 Mar;84(4):221-224. doi: 10.1055/s-0043-117838. Epub 2017 Aug 9.

Effects of Cannabidiol on Morphine Conditioned Place Preference in Mice.

Author information

1
Department of Psychology, University of Mississippi, University, MS, USA.
2
Research Institute of Pharmaceutical Sciences, University of Mississippi, University, MS, USA.
3
ElSohly Laboratories Inc., Oxford, MS, USA.
4
Department of BioMolecular Science, University of Mississippi, University, MS, USA.

Abstract

This study sought to determine whether the cannabis constituent cannabidiol attenuates the development of morphine reward in the conditioned place preference paradigm. Separate groups of mice received either saline or morphine in combination with one of four doses of cannabidiol using three sets of drug/no-drug conditioning trials. After drug-place conditioning, morphine mice displayed robust place preference that was attenuated by 10 mg/kg cannabidiol. Further, when administered alone, this dose of cannabidiol was void of rewarding and aversive properties. The finding that cannabidiol blocks opioid reward suggests that this compound may be useful in addiction treatment settings.

PMID:
28793355
DOI:
10.1055/s-0043-117838
[Indexed for MEDLINE]

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