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Cell Rep. 2017 Aug 8;20(6):1269-1277. doi: 10.1016/j.celrep.2017.07.031.

Human Gut-Derived Commensal Bacteria Suppress CNS Inflammatory and Demyelinating Disease.

Author information

1
Department of Immunology, Mayo Clinic, Rochester, MN 55901, USA; Department of Pathology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: ashutosh-mangalam@uiowa.edu.
2
Department of Pathology, University of Iowa, Iowa City, IA 52242, USA.
3
Department of Immunology, Mayo Clinic, Rochester, MN 55901, USA.
4
Division of Clinical Microbiology, Mayo Clinic, Rochester, MN 55901, USA.
5
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55901, USA.
6
Mayo Graduate School, Mayo Clinic, Rochester, MN, USA.
7
Department of Pathology, University of Iowa, Iowa City, IA 52242, USA; Iowa Institute of Human Genetics, University of Iowa, Iowa City, IA 52242, USA.
8
Department of Neurology, Mayo Clinic, Rochester, MN 55901, USA.
9
Department of Immunology, Mayo Clinic, Rochester, MN 55901, USA; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN 55901, USA.

Abstract

The human gut is colonized by a large number of microorganisms (∼1013 bacteria) that support various physiologic functions. A perturbation in the healthy gut microbiome might lead to the development of inflammatory diseases, such as multiple sclerosis (MS). Therefore, gut commensals might provide promising therapeutic options for treating MS and other diseases. We report the identification of human gut-derived commensal bacteria, Prevotella histicola, which can suppress experimental autoimmune encephalomyelitis (EAE) in a human leukocyte antigen (HLA) class II transgenic mouse model. P. histicola suppresses disease through the modulation of systemic immune responses. P. histicola challenge led to a decrease in pro-inflammatory Th1 and Th17 cells and an increase in the frequencies of CD4+FoxP3+ regulatory T cells, tolerogenic dendritic cells, and suppressive macrophages. Our study provides evidence that the administration of gut commensals may regulate a systemic immune response and may, therefore, have a possible role in treatment strategies for MS.

KEYWORDS:

EAE; Prevotella histicola; demyelination; experimental autoimmune encephalomyelitis; gut microbiome; human commensal; immunomodulation; inflammation; multiple sclerosis; regulatory T cells

PMID:
28793252
PMCID:
PMC5763484
DOI:
10.1016/j.celrep.2017.07.031
[Indexed for MEDLINE]
Free PMC Article

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