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Cell Rep. 2017 Aug 8;20(6):1262-1268. doi: 10.1016/j.celrep.2017.07.042.

Extended Interneuronal Network of the Dentate Gyrus.

Author information

1
Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA. Electronic address: szergely@stanford.edu.
2
Neuroscience Graduate Program, Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109, USA.
3
Department of Neurosurgery, Stanford University, Stanford, CA 94305, USA.
4
Neuroscience Graduate Program, Medical Scientist Training Program, University of Michigan, Ann Arbor, MI 48109, USA; VA Ann Arbor Healthcare System, Ann Arbor, MI 48109, USA.

Abstract

Local interneurons control principal cells within individual brain areas, but anecdotal observations indicate that interneuronal axons sometimes extend beyond strict anatomical boundaries. Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated within the CA regions back to granule cells. These results reveal the existence of a sophisticated retrograde GABAergic circuit that fundamentally extends the canonical interneuronal network.

KEYWORDS:

GABA; hippocampus; inhibition; network

PMID:
28793251
PMCID:
PMC5576513
DOI:
10.1016/j.celrep.2017.07.042
[Indexed for MEDLINE]
Free PMC Article

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