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J Diet Suppl. 2018 May 4;15(3):311-317. doi: 10.1080/19390211.2017.1345030. Epub 2017 Aug 9.

Rosa damascena Mill. Essential Oil Has Protective Effect Against Testicular Damage in Diabetic Rats.

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a Department of Basic Sciences, Faculty of Veterinary Medicine, Karaj Branch , Islamic Azad University , Alborz , Iran.
b Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine , Shiraz University , Shiraz , Iran.


This study investigates the protective effect of Rosa damascena essential oil on diabetes-induced testicular damage in rats. Thirty-six male Wistar rats were randomly divided into 6 equal groups: Group I: negative control (no treatment); Group II: positive control (diabetic by alloxan injection); Groups III-VI that rendered diabetic and received, respectively, 50, 100, 200, and 400 µg/kg/day rose oil, orally for 28 days. Rose oil did not significantly change body weight and blood glucose level as compared to positive control. Serum testosterone level of rose oil-treated rats remained statistically the same with both negative and positive control groups (Groups I and II). Rats treated with rose oil especially at 2 higher dosages (Groups V and VI) had higher sperm count and increased diameters of seminiferous tubules as compared to Group II. Rose oil even at the lowest dosage significantly increased cell count of spermatogonia, primary spermatocytes, Sertoli cells, and Leydig cells, with better outcomes for higher dosages. It appears that short-term repeated dose administration of rose oil can dose-dependently improve structural deteriorations of testes and epididymal sperm count in diabetic rats.


Rosa damascene; diabetes mellitus; essential oil; testicular damage

[Indexed for MEDLINE]

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