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Stem Cells Transl Med. 2017 Oct;6(10):1823-1828. doi: 10.1002/sctm.17-0047. Epub 2017 Aug 9.

Proceedings: Regenerative Medicine for Lung Diseases: A CIRM Workshop Report.

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California Institute for Regenerative Medicine, Oakland, California, USA.
Accendo Scientific, San Francisco, California, USA.
Children's Discovery and Innovation Institute, Broad Stem Cell Research Center, Jonsson Comprehensive Cancer Center, Departments of Pediatrics and Pulmonary Medicine, University of California, Los Angeles, California, USA.


The mission of the California Institute of Regenerative Medicine (CIRM) is to accelerate treatments to patients with unmet medical needs. In September 2016, CIRM sponsored a workshop held at the University of California, Los Angeles, to discuss regenerative medicine approaches for treatment of lung diseases and to identify the challenges remaining for advancing such treatments to the clinic and market approval. Workshop participants discussed current preclinical and clinical approaches to regenerative medicine in the lung, as well as the biology of lung stem cells and the role of stem cells in the etiology of various lung diseases. The outcome of this effort was the recognition that whereas transient cell delivery approaches are leading the way in the clinic, recent advances in the understanding of lung stem cell biology, in vitro and in vivo disease modeling, gene editing and replacement methods, and cell engraftment approaches raise the prospect of developing cures for some lung diseases in the foreseeable future. In addition, advances in in vitro modeling using lung organoids and "lung on a chip" technology are setting the stage for high quality small molecule drug screening to develop treatments for lung diseases with complex biology. Stem Cells Translational Medicine 2017;6:1823-1828.


Bioengineering; Cellular therapeutics; Clinical trials; Disease modeling; Engraftment; Gene therapy; In vivo imaging; Induced pluripotent stem cells; Lung; Lung diseases; Mesenchymal stromal cells; Organoids; Regenerative medicine; Stem cells

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