Format

Send to

Choose Destination
Acta Neurochir (Wien). 2017 Nov;159(11):2071-2080. doi: 10.1007/s00701-017-3286-x. Epub 2017 Aug 8.

Adolescents with moyamoya disease: clinical features, surgical treatment and long-term outcomes.

Zhao M1,2,3, Zhang D1,2,3, Wang S1,2,3, Zhang Y1,2,3, Wang R1,2,3, Deng X1,2,3, Gao F1,2,3, Zhao J4,5,6.

Author information

1
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing, People's Republic of China, 100050.
2
China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China.
3
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, People's Republic of China.
4
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, No. 6 Tiantanxili, Dongcheng District, Beijing, People's Republic of China, 100050. zhaojz205@163.com.
5
China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China. zhaojz205@163.com.
6
Center of Stroke, Beijing Institute for Brain Disorders, Beijing, People's Republic of China. zhaojz205@163.com.

Abstract

BACKGROUND:

This study aimed to elucidate the clinical features, surgical treatment and long-term outcomes of adolescent patients with moyamoya disease.

METHODS:

We reviewed consecutive patients with moyamoya vasculopathy who were admitted to our hospital from 2009 to 2015 to identify adolescent patients with moyamoya disease. Clinical features, surgical treatment and long-term outcomes were analyzed. Follow-up was performed by face-to-face or structured telephone interviews. Outcome measures were future stroke events. We performed univariate and multivariate time-to-event analyses to identify risk factors associated with future stroke events.

RESULTS:

A total of 95 adolescent patients with moyamoya disease (age at onset, 13.1 ± 2.3 years) were included in this study. During follow-up, 12 patients (12.6%) had stroke events. We found that the patients who underwent direct/combined bypass had a significantly lower risk of future strokes [hazard ratio (HR), 0.16; 95% confidence interval (CI), 0.03-0.74; P = 0.019] compared to patients who underwent indirect bypass.

CONCLUSIONS:

Our results demonstrate that direct/combined bypass can be more effective in preventing future strokes than indirect bypass in adolescent patients with moyamoya disease.

KEYWORDS:

Adolescent; Moyamoya disease; Outcome; Revascularization; Stroke

PMID:
28791519
DOI:
10.1007/s00701-017-3286-x
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Springer
Loading ...
Support Center