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Sci Rep. 2017 Aug 8;7(1):7522. doi: 10.1038/s41598-017-05106-5.

Prognostic value from integrative analysis of transcription factors c-Jun and Fra-1 in oral squamous cell carcinoma: a multicenter cohort study.

Author information

1
Department of epidemiology and health statistics, West China School of Public Health, Sichuan University, Chengdu, 610041, China.
2
Department of Oral Biology and Medicine, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, China.
3
School of Mathematics, Sichuan University, Chengdu, 610041, China.
4
Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, College of Stomatology, Chongqing Medical University, Chongqing, 400016, China.
5
Department of Oral Biology and Medicine, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, China. zhiyong.wang@scu.edu.cn.
6
Department of epidemiology and health statistics, West China School of Public Health, Sichuan University, Chengdu, 610041, China. qmchen@scu.edu.cn.
7
Department of Oral Biology and Medicine, State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, 610041, China. qmchen@scu.edu.cn.

Abstract

Transcription factors c-Jun and Fra-1 have been reported to play a role during the initiation and progression in oral squamous cell carcinoma (OSCC). However, cohort studies are rarely reported. Here is an integrative analysis of their prognostic value in OSCC through a multicenter cohort study.313 OSCC patients were included in this study and received regular follow-up. The survival rate and hazard ratios(HR) were generated by survival analysis. The concordance probability and receiver operating characteristic curve area were chosen to measure the model discrimination. High expressions of c-Jun or Fra-1 were associated with poor prognosis, meanwhile the high expression of Fra-1 meant worse prognosis of patients than the high expression of c-Jun. Besides, the interaction effect of c-Jun and Fra-1 was antagonism, when the expression of c-Jun and Fra-1 was both high, the HR was lower than the hazard ratio when only the Fra-1 was at high expression. c-Jun and Fra-1 were both proved to be high risky predictors of death in OSCC, the antagonistic effect suggested that these biomarkers' activities could be influenced by each other. It may provide a new sight for the studies of OSCC prognosis and treatment.

PMID:
28790303
PMCID:
PMC5548725
DOI:
10.1038/s41598-017-05106-5
[Indexed for MEDLINE]
Free PMC Article

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