Format

Send to

Choose Destination
Toxicol Lett. 2017 Oct 5;280:70-78. doi: 10.1016/j.toxlet.2017.07.899. Epub 2017 Aug 5.

Review of data on the dermal penetration of mineral oils and waxes used in cosmetic applications.

Author information

1
ToxMinds B.V.B.A., Avenue de Broqueville 116, B-1200 Brussels, Belgium. Electronic address: thomas.petry@toxminds.com.
2
L'Oréal Safety R&I, Worldwide Safety Evaluation, 9 rue Pierre Dreyfus, F-92110 Clichy, France.
3
Kao Germany GmbH, Pfungstädter Strasse 98-100, D-64297 Darmstadt, Germany.
4
Johnson & Johnson GmbH, Johnson & Johnson Platz 2, D-41470 Neuss, Germany.
5
IKW - The German Cosmetic, Toiletry, Perfumery and Detergent Association, Mainzer Landstrasse 55, D-60 329 Frankfurt am Main, Germany.
6
Procter & Gamble Service GmbH, Sulzbacher Str. 40, D-65824 Schwalbach am Taunus, Germany.
7
ToxMinds B.V.B.A., Avenue de Broqueville 116, B-1200 Brussels, Belgium.
8
Henkel AG & Co. KGaA, Henkelstraße 67, D-40589 Düsseldorf, Germany.
9
Beiersdorf AG, Unnastrasse 48, D-20245 Hamburg, Germany.

Abstract

Mineral oils and waxes used in cosmetic products, also referred to as "personal care products" outside the European Union, are mixtures of predominantly saturated hydrocarbons consisting of straight-chain, branched and ring structures with carbon chain lengths greater than C16. They are used in skin and lip care cosmetic products due to their excellent skin tolerance as well as their high protecting and cleansing performance and broad viscosity options. Recently, concerns have been raised regarding potential adverse health effects of mineral oils and waxes from dermal application of cosmetics. In order to be able to assess the risk for the consumer the dermal penetration potential of these ingredients has to be evaluated. The scope and objective of this review are to identify and summarize publicly available literature on the dermal penetration of mineral oils and waxes as used in cosmetic products. For this purpose, a comprehensive literature search was conducted. A total of 13 in vivo (human, animal) and in vitro studies investigating the dermal penetration of mineral oils and waxes has been identified and analysed. The majority of the substances were dermally adsorbed to the stratum corneum and only a minor fraction reached deeper skin layers. Overall, there is no evidence from the various studies that mineral oils and waxes are percutaneously absorbed and become systemically available. Thus, given the absence of dermal uptake, mineral oils and waxes as used in cosmetic products do not present a risk to the health of the consumer.

KEYWORDS:

Absorption; Cosmetic ingredients; Cosmetic products; Dermal penetration; Mineral oil; Paraffin waxes; Paraffinum; Personal care products; Petrolatum

PMID:
28789996
DOI:
10.1016/j.toxlet.2017.07.899
[Indexed for MEDLINE]
Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center