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Int J Mol Sci. 2017 Jul 28;18(8). pii: E1406. doi: 10.3390/ijms18081406.

Cellular Reparative Mechanisms of Mesenchymal Stem Cells for Retinal Diseases.

Author information

1
Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. suetlee.ding@gmail.com.
2
Department of Medical Microbiology and Parasitology, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. sureshkudsc@gmail.com.
3
Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. sureshkudsc@gmail.com.
4
Department of Biomedical Science, Faculty of Medicine and Health Sciences, University Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. rachelmok2005@gmail.com.
5
Genetics and Regenerative Medicine Research Centre, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. rachelmok2005@gmail.com.

Abstract

The use of multipotent mesenchymal stem cells (MSCs) has been reported as promising for the treatment of numerous degenerative disorders including the eye. In retinal degenerative diseases, MSCs exhibit the potential to regenerate into retinal neurons and retinal pigmented epithelial cells in both in vitro and in vivo studies. Delivery of MSCs was found to improve retinal morphology and function and delay retinal degeneration. In this review, we revisit the therapeutic role of MSCs in the diseased eye. Furthermore, we reveal the possible cellular mechanisms and identify the associated signaling pathways of MSCs in reversing the pathological conditions of various ocular disorders such as age-related macular degeneration (AMD), retinitis pigmentosa, diabetic retinopathy, and glaucoma. Current stem cell treatment can be dispensed as an independent cell treatment format or with the combination of other approaches. Hence, the improvement of the treatment strategy is largely subjected by our understanding of MSCs mechanism of action.

KEYWORDS:

MSC differentiation; anti-angiogenesis; anti-inflammatory; immunomodulatory; mesenchymal stem cells; paracrine activity; retinal degenerative diseases

PMID:
28788088
PMCID:
PMC5577990
DOI:
10.3390/ijms18081406
[Indexed for MEDLINE]
Free PMC Article

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