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Pediatr Infect Dis J. 2018 Jan;37(1):e22-e24. doi: 10.1097/INF.0000000000001732.

Optimizing Blood Collection and Processing for Quantiferon-TB Gold in-Tube Testing Gives Low Rates of Indeterminate Results: Clinical Implications.

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Department of Paediatrics, Division of Infectious Diseases, The Hospital for Sick Children, Department of Paediatrics, and Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada.


The rate of low-mitogen indeterminate interferon-gamma release assay results at a hospital with expert pediatric phlebotomy and rapid incubation of specimens was 0.96%. All low-mitogen indeterminate results were found to be associated with an immunocompromised or anergic state. We describe a child where an unexpected indeterminate interferon-gamma release assay test pointed to an underlying anergic condition and was of diagnostic significance.

[Indexed for MEDLINE]

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