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Pediatr Exerc Sci. 2018 Feb 1;30(1):96-105. doi: 10.1123/pes.2017-0067. Epub 2017 Nov 23.

Effect of Low- Versus High-Intensity Exercise Training on Biomarkers of Inflammation and Endothelial Dysfunction in Adolescents With Obesity: A 6-Month Randomized Exercise Intervention Study.

Author information

1
1 University of Pernambuco and Federal Institute of the Sertão Pernambucano.
2
2 Nemours Children's Clinic and Mayo Clinic College of Medicine.
3
3 Sogn and Fjordane University College.
4
4 Nine of July University.
5
5 University of Colorado Denver.
6
6 University of São Paulo.
7
7 Federal University of São Paulo-Santos.

Abstract

PURPOSE:

To investigate the effects of a low- versus high-intensity aerobic training on biomarkers of inflammation and endothelial dysfunction in adolescents with obesity.

METHODS:

Sixty-two adolescents with obesity [age = 15 (14) y, body mass index = 34.87 (4.22) kg·m-2] were randomized to receive either a high-intensity training (HIT, n = 31) or a low-intensity training (LIT, n = 31) for 24 weeks. All participants also received nutritional, psychological, and clinical counseling. Leptin, total and subtype leukocyte counts, tumor necrosis factor-alpha, interleukin-6, myeloperoxidase, soluble intercellular adhesion molecule-1, and soluble vascular cell adhesion molecule-1 were obtained at baseline and after 24 weeks.

RESULTS:

HIT reduced neutrophils [from 4.4 (1.9) to 3.6 (1.3) µL-1 × 103; P = .01] and monocytes [from 7.2 (2.5) to 5.2 (1.8) µL-1 × 102; P < .01], but LIT increased neutrophils [from 4.5 (1.7) to 5.2 (3.3) µL-1 × 103; P = .01]. Although tumor necrosis factor-alpha increased in LIT [from 13.3 (7.5) to 17.7 (10.8) pg·mL-1; P = .01], it decreased in HIT [from 12.4 (7.5) to 11.3 (6.2) pg·mL-1; P = .01]. No changes in leukocyte counts, soluble intercellular adhesion molecule-1, soluble vascular cell adhesion molecule-1, and homeostasis assessment model for insulin resistance were observed.

CONCLUSIONS:

Both HIT and LIT improved the inflammatory profile. The study, however, indicated that the number of biomarkers and the magnitude of changes were higher in the HIT compared with LIT.

KEYWORDS:

adiposity; aerobic exercise; inflammatory biomarkers; teenagers

PMID:
28787243
DOI:
10.1123/pes.2017-0067
[Indexed for MEDLINE]

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